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INOVIO DNA Medicines Will Meet Urgent Health Needs Worldwide JOURNAL of the JNCI NATIONAL CANCER INSTITUTE 42 HPV-Related Diseases • • Nearly 80M Americans are currently infected with HPV; ~14M become infected each year ~35k Americans get an HPV-attributable cancer per year, including head and neck and cervical, anal, penile and vulvar cancers ~23% of Americans age 18-59 have genital infections with 21 high-risk HPV genotype (e.g., HPV 16, HPV 18), which can lead to cervical, anal, head and neck, and other cancers; no current medicine to destroy/clear the virus ~4% of Americans age 18-69 have oral infection with ≥1 high-risk HPV genotype Other HPV genotypes (6/11) can cause debilitating conditions such as Recurrent Respiratory Papillomatosis (RRP), rare and potentially life-threatening in children and adults; only current treatment is multiple, lifelong surgeries HealthDay HPV Blamed for Rising Rates of Anal Cancer Nov 20, 2019, 12:00 pm By Steven Reinberg HealthDay ReporterWEDNESDAY, Nov. 20, 2019 (HealthDay News) Anal cancer rates have surged in the past 15 years, and the sexually transmitted human papillomavirus (HPV) may CAN health "People New Study Reveals a Rise in Anal Cancer Rates and Deaths in the United States A majority of the cases observed by researchers were caused by the human papillomavirus By Claudia Harmata November 20, 2019 02:04 PM f FB Twitter LOOK LELESS NAS P People Η ΠΑΕ 11 сара σ = The Washington Post The Washington Post Derne D Amer Medical Mysteries Top tools Anal cancer rates and deaths are climbing in the US, study says By Kristen Rogers, CNN Updated 10-27 PM ET, Tue November 19, 2019 PIAGET THOUSANDS IRIT ARDS Heineken OF CLICKS OR ONE GI Mome Try 1 month for SL A toddler's dwindling voice was chalked up to acid reflux. Her problem was far more serious. INSIDE edition A Tax Solution Woman With Raspy Voice Has Had More Than 300 Surgeries to Treat Rare Vocal Cord Disease HEALTH 235PM PDT. April 11, 20 JOHANNA LI INOVIO POWERING DNA MEDICINES

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