Unlocking Hope for Cancer Patients Using PDT

NON-MELANOMA SKIN CANCER (NMSC) THE WORLD'S MOST COMMON CANCER : SKIN CANCER4 23 23 Australia: Highest skin cancer incidence globally2 SCC -19% Melanoma -1% NMSC: Incidence rates (2020)2 per 100,000 Epidermis Others -1% Dermis 150 114.9 100 64.4 Hypodermis Muscle layer 50 16 BCC -79% 1.5 0 Australia &... USA & Canada Europe Asia Non-Melanoma Skin Cancer¹ 5-Yr Prevalence Worldwide 6.5M2 BCC: Basal Cell Carcinoma | SCC: Squamous ell Carcinoma | MCC: Merkel Cell Carcinoma EPIDEMIOLOGY AND RISK FACTORS³ BASAL-CELL CARCINOMA Basl cell Skin (NMSC) Basement membrane Melanocyte Basal cell carcinoma SQUAMOUS-CELL CARCINOMA Ulcer Hard raised edges. Dead keratinocyte Keratinocyte Cancer cell Stratum corneum Epidermis Dermis Hypodermis Muscle layer • • Major factor: UV-rays exposure Genetics: Family history of skin cancer Skin pigmentation: Fair-skinned > Dark-skinned • Age: Older individuals • Gender: Men > Women Association: Human Papilloma Virus, certain chemicals UNMET MEDICAL NEEDS Standard treatment option: Surgery, often leads to scarring and pain Inconsistent treatment outcomes Side effect management (radiotherapy, brachytherapy, chemotherapy) Need for more effective and less invasive treatment options for advanced cases https://www.cancer.net/cancer-types/skin-cancer-non-melanoma/introduction 2 Source GLOBOCON 2020, WHO 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432795/ 4 https://amp.cancer.org/cancer/types/melanoma-skin-cancer/about/key-statistics.html INVION

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