Q1 2023 Results slide image

Q1 2023 Results

Company overview Financial review Conclusions Appendix References LeqvioⓇ adoption expanding as we progress the launch GROWTH LEQVIO® Addressing non-clinical barriers in US Adoption Adoption Facilities having ordered LeqvioⓇ HCPS2 with LeqvioⓇ experience US LeqvioⓇ launch tracking EntrestoⓇ US sales evolution USD m 50 +29% +33% 40 30 EntrestoⓇ 20 LeqvioⓇ 2,200 9,600 10 1,400 1,700 7,200 4,800 0 6 12 18 24 30 30 36 Q3 2022 Q4 2022 Q1 2023 Q3 2022 Q4 2022 Q1 2023 Months since launch Access Adherence Patients covered Patients coming for at or near label³ 76% 2nd dose within <95 days4 75% Global sales evolution USD m 64 Ex-US US 42 34 22 14 Q1 2022 Q2 2022 Q3 2022 Q4 2022 Q1 2023 HCP healthcare professional. *Leqvio® is administered initially, again at 3 months, and then 1. Either an alternate site of care or a physician practice. 2. Either prescribe LeqvioⓇ to a patient based on service center data, data on file or have ordered through Free Trial Offer program. 3. As of April 10, 2023. 4. Refers to average duration in between doses. Based on IQVIA and data shared by infusion management and ambulatory infusion center companies. once every 6 months. Novartis has obtained global rights to develop, manufacture and commercialize LeqvioⓇ under a license agreement with Alnylam Pharmaceuticals. 17 Investor Relations | Q1 2023 Results ✓ NOVARTIS | Reimagining Medicine
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