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Investor Presentaiton

Performance: 2022 results and total to adjusted reconciliation Turnover Operating (£bn) profit (£bn) 2022 EPS (pence) 2021 EPS (pence) Key dynamics 371.4 109.6 Total results - Total Profit from discontinued operations (260.6) (26.7) Total results - Continuing 29.3 6.4 110.8 82.9 operations Intangible amortisation 0.7 14.6 15.2 Intangible impairment 0.3 5.8 6.6 Major restructuring 0.3 5.9 8.7 Profit from discontinued operations ⑦Gain on demerger (fair value less book value) ⑰ Gain on retained stake on demerger (fair value less book value) Transaction related ✓ ViiV contingent consideration liability movements (majority FX¹) Divestments, significant legal and other ↑ Upfront income from the settlement with Gilead ↑ Fair value mark to market gain on the retained stake in Haleon Transaction related 1.8 34.1 18.1 Divestments, significant (1.4) (31.5) (21.2) legal and other Turnover: £29.3bn², 19% at AER, +13% at CER (ex-pandemic³ +10% CER) Adj. OP4: £8.2bn², +26% at AER, +14% at CER (ex-pandemic³ +17% CER) Adj. EPS: 139.7p², +27% at AER, +15% at CER (ex-pandemic³ +18% CER) Adjusted results 29.3 8.2 139.7 110.3 Table may not sum due to rounding. See page 18 of GSK's fourth quarter 2022 earnings release for a full reconciliation. 1. Foreign exchange 2. Continuing results represents performance excluding discontinued operations 3. excluding COVID-19 solutions 4. Operating profit GSK 21
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