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Investor Presentaiton

Company overview Financial review 2022 priorities Appendix References 2022 full year guidance Expected, barring unforeseen events; growth vs. PY in cc Innovative Medicines Sales to grow mid single digit Core Oplnc to grow mid to high single digit, ahead of sales Sales to grow low single digit (revised upwards from broadly in line) Sandoz Core Oplnc to be broadly in line with prior year (revised upwards from to decline low to mid single digit) Sales to grow mid single digit Group Core Oplnc to grow mid single digit Key assumptions Our guidance assumes that we see a continuing return to normal global healthcare systems, including prescription dynamics, and that no GilenyaⓇ and no SandostatinⓇ LAR generics enter in the US. In June 2022, an appeals court held the Gilenya US dosing regimen patent invalid. Novartis plans to petition the appeals court for further review to uphold validity of the dosing regimen patent. There is no generic competition in the US at this time. In Q2, Gilenya US sales were USD 332m, US sales have been steadily declining due to competitive pressures. 23 Investor Relations | Q2 2022 Results 1 NOVARTIS | Reimagining Medicine
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