Fourth Quarter & Full Year 2022 Financial & Business Update

4Q and Full Year 2022 Financial Results Conference Call Agenda Introduction Business Review Commercial Performance Financial Performance Research & Development Q&A Seagen Douglas Maffei, Ph.D. - Vice President, Investor Relations David Epstein - Chief Executive Officer Chip Romp - Executive Vice President, Commercial U.S. Todd Simpson - Chief Financial Officer Roger Dansey, M.D. - President, Research and Development 3

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