Novo Nordisk Investor Presentation - First Nine Months of 2016

Investor presentation First nine months of 2016 Oral peptide delivery - the gastro-intestinal route poses many challenges to absorption of intact macromolecules Slide 73 Challenges 1. Breakdown of drug in the stomach/gastrointestinal tract 2. Passage across the gut barrier into the circulation 3. Ensuring a long circulation half-life Solutions 1. Stabilisation of peptide backbone and side chain 2. Tablet formulation including carrier and/or coating 3. Engineered systemic protraction mechanism changing diabetes novo nordisk

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