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Investor Presentaiton

ENHERTU Performance in Each Region (US, EU) Global product sales: FY2023 Q1 results 81.7 Bn JPY (YOY +50.4 Bn JPY) FY2023 forecast 320.0 Bn JPY (YOY +112.5 Bn JPY) >ENHERTU US trastuzumab deruxtecan 51.6 Bn JPY 20.0 Bn JPY 6.7 Bn JPY 17.8 Bn JPY FY2022 Q1 FY2023 Q1 FY2022 Q1 FY2023 Q1 US Europe Daiichi-Sankyo Product sales: FY2023Q1 results 51.6 Bn JPY (375 Mn USD) FY2023 forecast 195.1 Bn JPY (1.5 Bn USD) Indication: HER2+ mBC 2L+, HER2 low mBC (post-chemo), HER2+ mGC 2L+, HER2 mutant mNSCLC 2L+ Market share status HER2+ mBC 2L: Maintaining No.1 new patient share HER2 low mBC: Maintaining No.1 new patient share and growing further HER2+ MGC 2L: Maintaining No.1 new patient share HER2 mutant mNSCLC 2L: Maintaining No.1 new patient share Europe Product sales: FY2023Q1 results 17.8 Bn JPY (130 Mn USD) FY2023 forecast 75.8 Bn JPY (583 Mn USD) Indication: HER2+ mBC 2L+, HER2 low mBC (post-chemo), HER2+ MGC 2L+ Market share status HER2+ MBC 2L: Maintaining No.1 new patient share in France, Germany and Spain HER2 low mBC: Achieved No.1 new patient share in France and Germany Other progress Launched in Italy (Jul. 2023) 12
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