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Investor Presentaiton

Key Business Performance TruximaⓇ In Europe, the market share has decreased during the transition to go direct in 1H22, expected to be recovered gradually with the start of direct sales in 2H22 ✓ Despite pricing pressure amid intensified competition, maintaining stable market share in the US M/S of TruximaⓇ in Europe M/S of TruximaⓇ in the US 18% 39% 40% 35% 38% 37% 36% 31% Volume 20.1Q 2Q 3Q 4Q 21.1Q 2Q 3Q 4Q 22.1Q 2Q 3Q TruximaⓇ D Biosimilar Value 29% 24% 17.4Q 18.2Q 4Q 19.2Q 4Q 20.2Q 4Q 21.2Q 4Q 22.2Q 20.1Q 2Q 3Q 4Q 21.1Q 2Q 3Q 4Q 22.1Q 2Q 3Q MabtheraⓇ Truxima a® C Biosimilar TruximaⓇ D Biosimilar Note: The market share is based on volume Source: IQVIA Source Symphony Health Investor Relations 2022 11 37% 28% 32% 28%
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