Kymera IPO Presentation Deck

IRAK4 Degradation Superior to Kinase Inhibition in Cytokine Production - Functional activity of KT- 474 assessed by measuring pro- inflammatory cytokine levels upon activation . Cells pre-treated with KT-474, a negative control, and two small molecule IRAK4 kinase inhibitors KT-474 better able to inhibit IL-6 under both LPS and R848 than clinically active IRAK4 SM kinase inhibitor PF-06550833 KYMERA 9-71% 150 100- 50 -8 Legend LPS → IL-6 Log [Compound] (uM) Compound KT-474 Negative control IRAK4 SMI (PF-06550833) IRAK4 SMI (other) IL-6 IC (nm) 3 335 N/A N/A 9-71% 150 100 50 -8 R848 → IL-6 -2 Log [Compound] (µM) Legend Compound KT-474 IRAK4 SMI (PF-06550833) IRAK4 SMI (other) IL-6 IC (nM) 0.7 5 49

View entire presentation