Comera Investor Presentation Deck

SQore: Validated by Scientific Peer-Review Caffeine-based lead SQore excipient proven in externally validated, rigorous scientific evaluation to achieve all desired target parameters for a viable SQ formulation • Lead SQore excipient, caffeine, used to show SQ formulation proof of concept for two leading mAbs • Remicade INFLIXIMAB YERVOY. (ipilimumab) Significant viscosity reduction. No effect on mAb stability No loss of biological activity ELSEVIER Journal of Pharmaceutical Sciences Volume 104 Number 12 December 2015 Contents lists available at ScienceDirect Journal of Pharmaceutical Sciences journal homepage: www.jpharmsci.org Pharmaceutics, Drug Delivery and Pharmaceutical Technology Caffeine as a Viscosity Reducer for Highly Concentrated Monoclonal Antibody Solutions *ReForm Biologics Inc., 12 Gill Street Suite 4650, Woburn, MA 01801, United States bKBI Biopharma Inc., 1101 Hamlin Rd, Durham, NC 27704, United States Yuhong Zenga,*, Timothy Tran, Philip Wuthrich, Subhashchandra Naik, Juan Davagnino, Daniel G. Greeneª,1, Robert P. Mahoney, David S. Soane ( Source: "Caffeine as a viscosity reducer for highly concentrated monoclonal antibody solutions", Journal of Pharmaceutical Sciences, 110 (2021) 3594-3604, https://doi.org/10.1016/j.xphs.2021.06.030 ADVANCING Comera APhA LIFE SCIENCES Check for updates APA American i farmacists Association Improving medication use. Advancing patient care View this journal online at wileyonlinelibrary.com 12

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