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Investor Presentaiton

Company overview Financial performance Oncology Financial review 2022 priorities Appendix Innovation: Pipeline overview Innovation: Clinical trials Immunology Ophthalmology Neuroscience Respiratory Disease sabatolimab - TIM3 antagonist NCT04150029 STIMULUS-AML1 (CMBG453C12201) Indication Unfit acute myeloid leukaemia Phase 2 Phase Patients 86 Primary Outcome Measures Arms Intervention Incidence of dose limiting toxicities (Safety run-in patients only) Percentage of subjects achieving complete remission (CR) Single arm safety and efficacy study of sabatolimab in combination with azacitidine and venetoclax Target Patients Newly diagnosed adult AML patients who are not suitable for treatment with intensive chemotherapy Read-out Milestone(s) 2023 Publication TBD References Abbreviations Cardio-Renal Global Health Biosimilars 61 Investor Relations | Q2 2022 Results NOVARTIS | Reimagining Medicine
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