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Investor Presentaiton

• Highlights of additional MRD studies underway INVESTOR 20 DAY 23 Near-term readouts Breast Cancer Clinical Validity Study • Post-adjuvant chemoRx cohort Submitted to San Antonio Breast Cancer Symposium (SABCS) > 300 early breast cancer patients across all subtypes • Median follow-up of 66 months • GUARDANT™ PEGASUS De-Escalation Clinical Utility Trial (Standard of Care Chemotherapy) CRC Long-term readouts TRACC Part C De-Escalation Clinical Utility Trial (Standard of Care Chemotherapy) CRC • • Ph II single-arm study Ph III randomized control trial • Data readout submitted to ESMO • Study enrollment ongoing 140 high-risk stage II & stage III colon cancer patients after surgical resection Study fully enrolled in 2022. • • 1621 high-risk stage II & stage III colon cancer patients after surgical resection Expect to complete enrollment in early 2027 69 69
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