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Investor Presentaiton

Daiichi-Sankyo ENHERTU Performance in Each Region (Japan, ASCA) Steady increase in product sales due to market penetration and increasing launched countries/regions Global product sales: FY2022 Q1 results 31.3 Bn JPY (YOY +18.4 Bn JPY) FY2022 forecast 128.4 Bn JPY (YOY +63.0 Bn JPY) Japan ASCA Product sales: FY2022 Q1 results 2.4 Bn JPY (19 Mn USD) FY2022 forecast 16.0 Bn JPY (123 Mn USD) Product sales: FY2022 Q1 results 2.2 Bn JPY (17 Mn USD) FY2022 forecast 6.3 Bn JPY (48 Mn USD) Indication: HER2+ BC 3L, HER2+ GC 3L Market share status ➤ HER2+ BC 3L: Maintaining No.1 new patient share HER2+ GC 3L: Maintaining No.1 new patient share Other progress Classified as a preferred regimen for HER2+ BC 2L treatment in guidelines (Jun.2022) Indication: HER2+ BC 2L/3L Market share status Sales growing in Brazil, Hong Kong and Taiwan Other progress Launched in Taiwan (Apr. 2022) ENHERTU® trastuzumab deruxtecan 13
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