Investor Presentation H1 2023

4 Investor presentation First six months of 2023 Novo NordiskⓇ Strategic Aspirations 2025 | Highlights first six months of 2023 sustainability Purpose and (ESG) Progress towards zero environmental impact Carbon emissions decreased by 28% vs H1 20191 Adding value to society Medical treatment provided to 39.1 million people living with diabetes (net increase of 4 million people) Reaching more than 45,000 children in Changing Diabetes in Children programme Being recognised as a sustainable employer Share of women in senior leadership positions has increased to 40% from 38% at end of June 2022 therapeutic focus Innovation and . • e • Light blue indicates developments in Q2 2023 Further raise innovation bar for Diabetes treatment Regulatory submission of once-weekly insulin icodec Completion of phase 3 trial PIONEER PLUS Develop superior treatment solutions for obesity Completion of phase 3 SELECT trial Completion of phase 3 trial OASIS 1 Completion of phase 3 trial STEP HFPEF Acquisition of Inversago Pharma Strengthen and progress Rare Disease pipeline Somapacitan approved in US, EU, JP for GHD in children Establish presence in Other serious chronic diseases Commercial execution Diabetes value market share increased by 1.7%-points to 32.7%² Obesity care sales of DKK 18.1 billion (+157% at CER) Rare disease sales of DKK 8.7 billion (-18% at CER) Financials Sales growth of 30% (CER) and operating profit growth of 32% (CER) Operational leverage reflecting sales growth Free cash flow of DKK 45.5 billion and DKK 32.4 billion returned to shareholders 1 Scope 1,2 and partial scope 3 limited to CO2 emissions from business flights and product distribution; 2 MAT (Moving annual total) value market share Note: The strategic aspirations are not a projection of Novo Nordisk's financial outlook or expected growth H1: First half; HFPEF: Heart Failure with preserved ejection fraction; US: United States; EU: Europe; JP: Japan; GHD: Growth Hormone Deficiency; CER: Constant exchange rates

View entire presentation