Investor Presentation Q1 2023

121 Investor presentation First three months of 2023 Insulin market size and volume market share in Rest of World Insulin market share and market size (DKK billion) Total 58% 42% Long- acting 62% Fast- acting 2 Premix 83% 2 Human 67% 2 5 Novo Nordisk Competitors Rest of World Market growth A Market share Insulin volume: Market share 80% 20% 12 6.3% +1.1% 60% 15% 58% 10% 8.2% +1.8% 40% 5% 4.5% +0.7% 20% 0% -4% -4% -5% 6.5% +0.7% 0% Feb 2020 4.2% +1.3% -NN market share Source: IQVIA, Feb 2023; LHS graph - Value, RHS Graph - Volume, MAT; Share of growth not depicted due to too high numbers; NN: Novo Nordisk -10% Feb 2023 -Market growth (right axis) -NN growth (right axis)

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