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Investor Presentaiton

GLP-1 class expansion continues in the US with volume growth across our portfolio in the fourth quarter of 2022 8 Investor presentation Full year 2022 US GLP-1 weekly NBRx prescriptions Weekly NBRX scripts ('000s) 60 60 50 40 40 30 20 10 Novo NordiskⓇ US GLP-1 TRX market share TRX share Total GLP-1 scripts (millions) 60% Class growth -50% 5 50.3% 4 37.2% 40% 3 31.5% 2 20% 16.7% 7.6% 1 5.9% 0% 0 Jan 2023 Jan 2021 Jan 2023 VictozaⓇ NN GLP-1 dulaglutide tirzepatide Total monthly GLP-1 scripts 0 Jan 2021 Ozempic RybelsusⓇ Source: IQVIA Xponent, NBRX data from week ending 13 Jan 2023. TRX data from week ending 13 Jan 2023. Each data points represents a rolling four-week average NBRX: New-to-brand prescriptions; TRX: Total prescriptions; NN: Novo Nordisk; Scripts: Prescriptions Note: Class growth calculated as Q4 2022 vs Q4 2021
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