Akouos IPO Presentation Deck

Multimodal Capabilities Create Potential to Address a Broad Range of Monogenic and Non-Monogenic Inner Ear Disorders. Akouos Precision Genetic Medicine Platform Gene Editing 22 Modality Target Hair Cells Supporting Cells Secreted Proteins Gene Transfer Single Vector CLRN1 GJB2 Dual Vector OTOF Gene Knockdown RNA-interference Hair Cell Regeneration Nuclease- based Undisclosed autosomal dominant indications Non- nuclease- based CONFIDENTIAL AKOUOS Therapeutic Protein Expression Vestibular Schwannoma Initial pipeline spans multiple vector-mediated modalities and cochlear targets to potentially address inner ear disorders affecting hundreds of thousands of individuals in the U.S. and Europe

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