Charles River - JP Morgan Conference Presentation

Charles River - JP Morgan Conference Presentation Research Models and Services Revenue Operating income Operating income as a % of revenue Add back: Amortization related to acquisitions Severance CHARLES RIVER LABORATORIES INTERNATIONAL, INC. RECONCILIATION OF GAAP TO NON-GAAP SELECTED BUSINESS SEGMENT INFORMATION (UNAUDITED)(¹) (in thousands, except percentages) $ Three Months Ended December 25, 2021 December 26, 2020 165,575 $ 40,188 24.3% 156,697 S 34,381 21.9% Twelve Months Ended December 25, 2021 December 26, 2020 690,437 $ 166,814 24.2% 571,152 102,706 18.0% Acquisition related adjustments (2) 4,075 3,975 118 359 876 20,104 19,556 7 645 1,576 2,375 Site consolidation costs, impairments and other items 200 Total non-GAAP adjustments to operating income Operating income, excluding non-GAAP adjustments Non-GAAP operating income as a % of revenue $ 4,434 $ 4,969 S 21,687 $ 22,776 $ 44,622 $ 39,350 S 188,501 $ 125,482 26.9% 25.1 % 27.3% 22.0% Depreciation and amortization Capital expenditures $ 9,673 $ $ 31,667 $ 9,747 13,902 S 39,123 $ 37,080 S 61,188 $ 29,487 Discovery and Safety Assessment Revenue Operating income Operating income as a % of revenue Add back: Amortization related to acquisitions Severance Acquisition related adjustments (2) Site consolidation costs, impairments and other items Total non-GAAP adjustments to operating income Operating income, excluding non-GAAP adjustments Non-GAAP operating income as a % of revenue Depreciation and amortization Capital expenditures Manufacturing Solutions Revenue Operating income $ 534,136 $ 94,967 17.8% 495,004 91,087 18.4% S 2,107,231 $ 406,978 1,837,428 325,959 19.3% 17.7% 19,933 21,978 84,740 90,304 (144) 130 1,016 4,117 8,016 828 4,374 3,673 844. 726 2,098 6,598 $ 28,649 $ 23,662 $ 92,228 $ 104,692 $ 123,616 $ 114,749 $ 499,206 $ 430,651 23.1% 23.2% 23.7% 23.4 % $ $ 44,986 $ 40,694 $ 43,784 S 177,254 $ 168,922 59,217 S 101,477 $ 105,653 $ 205,339 $ 91,673 139,289 49,206 S 742,492 $ 515,353 246,390 181,494 44.6% 35.3% 33.2% 35.2% Operating income as a % of revenue Add back: Amortization related to acquisitions 5,390 2,144 23,304 8,758 Severance 1,278 428 3,622 2,413 Acquisition related adjustments (2) (25,281) (20,437) (421) Site consolidation costs, impairments and other items (3) 217 151 1,331 320 Total non-GAAP adjustments to operating income $ (18,396) $ 2,723 S 7,820 $ 11,070 Operating income, excluding non-GAAP adjustments Non-GAAP operating income as a % of revenue $ 73,277 $ 51,929 S 254,210 $ 192,564 35.7% 37.3% 34.2% 37.4% Depreciation and amortization Capital expenditures CONTINUED ON NEXT SLIDE $ 11,721 $ 6,647 S 46,195 $ 25,904 $ 24,869 $ 12.302 $ 58,877 $ 26.287 27 27

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