Investor Presentaiton

R&D investor presentation IL-6 antibody is targeting inflammation-driven CVD in patients with CKD Pattern Recognition Moieties including NLRP3 M1 Macrophage Vascular calcification M2 Macrophage Th17 Osteoclast Cytokines, Ox LDL AGE Hypoxia Thrombin IL-1ẞ, other cytokines Treg IL-6: Interleukin 6; CVD: Cardiovascular disease; CRP: C-reactive protein Monocyte/ Macrophages Endothelial Smooth Muscle Cells Ceils IL-6 Cardiomyocytes Cardiomyocyte injury Collagen deposition/ Cardiac Fibrosis CRP, SAA, Fibrinogen 26

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