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Financial Guidance and Company Overview

GAAP to Non-GAAP Reconciliation: Net Income and Diluted EPS 2022 Guidance $ U.S. in Millions, except EPS (unaudited) GAAP Net Income Adjustments: Inducement expense related to convertible notes Share-based compensation Amortization of debt discount Income tax benefit.. Income tax effect of above adjustments Non-GAAP Net Income GAAP Diluted EPS Adjustments: Inducement expense related to convertible notes. Share-based compensation Amortization of debt discount. Halozyme Income tax benefit Income tax effect of above adjustments Non-GAAP Diluted EPS GAAP & Non-GAAP Diluted Shares 2022 2021 270-295 $ 402.7 21.0 22-25 20.8 4-4 3.9 (154.2) (6) - (7) (0.1) $ 290-315 $ 294.1 1.90 2.05 $ 2.74 0.14 0.16 -0.17 0.14 0.04 -0.04 0.03 (1.05) (0.04) - (0.05) $ 2.052.20 $ 2.00 142-143 146.8 Dollar amounts, as presented, are rounded. Consequently, totals may not add up. 19
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