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Investor Presentaiton

Investor presentation Full year 2018 Slide 36 Region Japan & Korea at a glance Diabetes trend in population Diabetes market by value and Novo Nordisk market share Novo Nordisk reported sales Million 16 Population with diabetes Diabetes growth rate NN Insulin MS NN OAD MS bDKK 40 NN GLP-1 MS Full year 2018 Sales (mDKK) Growth² 80% Long-acting insulin³ 857 1% -9% 20% Premix insulin4 650 (4%) 12 30 31.1%¹ +60% 12 11 GLP-1 Insulin Fast-acting insulin5 779 (15%) Human insulin 187 (17%) 12 (2.1%)¹ 8 - 20 40% Total insulin 2,473 (7%) GLP-16 614 7% 4.8%¹ OAD Other diabetes care? 368 1% 4 10 + 20% Diabetes care 3,455 (4%) Obesity (SaxendaⓇ) 175 0 2000 2017 2045 Nov 2013 0% Biopharm³ 2,167 Nov 2018 (6%) Total 5,797 (2%) Japan & Korea population 2018: ~0.2 billion people and diabetes prevalence ~8.0% Source: International Diabetes Federation: Diabetes Atlas 1th Edition 2000 and Diabetes Atlas 8th Edition 2017 1 CAGR calculated for last 5-year period Competitor value market share comparison for insulin as of Nov 2018: Novo Nordisk 57%, Eli Lilly 22% and Sanofi 21% Competitor value market share comparison for GLP-1 as of Nov 2018: Novo Nordisk 33%, Eli Lilly 61%, Sanofi 3% and AstraZeneca 3% OAD: Oral anti-diabetic; MS: Market share Source: IQVIA MAT Nov, 2018 value figures 2 Percentage change in local currency from full year 2017 to full year 2018 3 Comprises TresibaⓇ and Levemir®: 4 Comprises NovoMix® and RyzodegⓇ; 5 Comprises NovoRapidⓇ; 6 Comprises VictozaⓇ; 7 Comprises NovoNormⓇ and needles; 8 Comprises primarily NovoSeven®, NovoEight® NovoThirteenⓇ and NorditropinⓇ
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