Novavax Global Commercial Operations and COVID-19 Vaccine Update

Novavax booster after EUA vaccines increases MN responses Last dose of EUA vaccines >6 months prior to Novavax dose, 28 days post-boost Primary series of EUA vaccines + Novavax booster Primary series & boost of EUA vaccines + Novavax booster Neutralization GMT (ID50) with 95% CI 10,000 93% VE* 4,200 1,000 82% VE 100 2,907 2,486 1,983 12,178 93% VE* 82% VE* 4,064 3,265 2,499 10 2 doses NVX 2 doses PFE 2 doses MOD 1 dose J&J 3 doses NVX 3 doses PFE 3 doses MOD 2 doses J&J + NVX boost N=7 + NVX boost N=190 + NVX boost N=131 + NVX boost + NVX boost + NVX boost N=19 N=4 N=260 + NVX boost N=134 + NVX boost N=6 novavax *CoP from Fong et al., 2023. DOI: 10.1038/s41467-022-35768-3 Validated assay conducted by 360biolabs © 2023 NOVAVAX. All rights reserved. 49

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