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CONTINUOUS TREATMENT LEADS TO SIGNIFICANTLY LESS VARIABILITY ILUVIEN CST (μm) 800 700 600 500 400 300 200 100 0 CST ETDRS Letters (fluocinolone acetonide intravitreal implant) 0.19mg ILUVIEN alimera (fluocinolone acetonide intravitreal implant) 0.19mg 90 80 70 60 50 40 36 33 30 27 24 21 18 15 12 9 6 3 0 3 6 9 12 15 18 21 24 27 30 33 36 39 Months CST is a measure of retinal thickness (anatomical outcome). VA(ETDRS) is a measure of visual acuity (functional outcome). Case study from Dilsher Dhoot, MD; Used with permission. Data on File; Alimera Sciences, Inc. 30 20 10 VA (ETDRS Letters) 10

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