EVOLUTION AT MERCK - INVENTING FOR LIFE

GEFAPIXANT (MK-7264): EXPLORING ROLE OF P2X3 PATHWAY IN DISORDERS OF SENSORY PATHOLOGY MERCK INVENTING FOR LIFE Pathologically sensitized afferents send aberrant signals of disease Sensory Pathology P2X3 Blockade ⚫ Headache/migraine ⚫ Hypertension •Pathologic cough • Bronchoconstriction • Breathlessness Sleep apnea ⚫ IBS-C/D • Urinary urgency • Bladder/pelvic pain • Endometrial-related pain ⚫ Neuropathic pain • Muscle pain Blocking P2X3 receptors restores normal sensory function Development focused on the role of P2X3 receptor mediated signaling in: Unexplained or refractory chronic cough • Visceral pain syndromes • Altered sympathetic function • Itch Pathologies currently being explored Dr. Roy Baynes | 71

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