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Investor Presentaiton

Biome Australia CLINICAL TRIAL 50% 40% 30% 20% 10% PRE POST 24HR 48HR 72HR 0% -10% -20% Figure 1. Percent change of interleukin-6 (pro-inflammatory cytokine) compared to baseline before and after exercise. Biome Recovery™ Probiotic Placebo Company Presentation | August 2023 Commercial in confidence Key Product Research A double-blind, randomised, placebo-controlled trial investigated the effect of the probiotic formulation in Biome RecoveryTM Probiotic on physical performance and levels of inflammation following muscle-damaging exercise in healthy men. After 3 weeks of supplementation, the probiotic helped to reduce the negative effect of muscle damage on performance, improved range of motion following muscle-damaging exercises, and lowered levels of the pro-inflammatory cytokine interleukin-6 at baseline and up to 48 hours post-exercise. Jäger, R., Purpura, M., Stone, J. D., Turner, S. M., Anzalone, A. J., Eimerbrink, M. J., Pane, M., Amoruso, A., Rowlands, D. S., & Oliver, J. M. (2016). Probiotic Streptococcus thermophilus FP4 and Bifidobacterium breve BR03 supplementation attenuates performance and range-of-motion decrements following muscle damaging exercise. Nutrients, 8(10), 1-11.
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