Investor Presentaiton

Three key Research principles to improve R&D productivity Causal human biology Application of human data (e.g., genetics, longitudinal profiling of patient samples) for rigorous target validation in drug discovery Matching modality to mechanism 88 Path to clinical proof-of-concept Invention of high-quality therapeutics that match a modality to a molecular mechanism of action Targeted patient selection (e.g., biomarkers) and clear translational endpoints for improved clinical success Our ambition is to increase the number of INDs with transformational potential and increased probability of success across all stages of clinical development Ill Bristol Myers Squibb™ Not for Product Promotional Use 17

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