EVOLUTION AT MERCK - INVENTING FOR LIFE slide image

EVOLUTION AT MERCK - INVENTING FOR LIFE

KEYTRUDA: SIGNIFICANT GLOBAL GROWTH OPPORTUNITIES • Building on leadership in lung with additional reimbursement rolling out across Europe and other markets $10,000 KEYTRUDA is one of the best-selling drugs 6 years after launch $9,000 • Encouraged by early adoption in RCC and adjuvant melanoma launches $8,000 $7,000 • Excited to extend H&N leadership with recent 1L approval $6,000 Indications expected to more than double over next 5 years O Earlier lines of therapy, including adjuvant / neoadjuvant 。 New combinations 。 New tumor types $5,000 $4,000 $3,000 $2,000 $1,000 KEYTRUDA (pembrolizumab) 100 LIPITOR atorvastatin calcium OPDIVO. (nivolumab sabers $0 Year 1 Year 2 Year 3 Year 4 Year 5 Year 6 Source: Evaluate Pharma; KEYTRUDA Year 6 sales represent 1Q 2019 sales annualized. Sales in $ billions and not inflation adjusted MERCK INVENTING FOR LIFE # Frank Clyburn 20
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