Certara Investor Day Presentation Deck

Pain points in clinical phase significant opportunity Clinical Data Workflow CLINICAL DATA STANDARDIZATION STUDIES AND COMPLIANCE ● Growing number and diversity of data sources --> longer database lock cycle times • Lack of data governance Manual data management Customer Pain Points and Opportunities Sub-optimal trial design Patient recruitment challenges BIOSIMULATION AND DATA ANALYSIS ● • ~50% of compounds fail due to safety, efficacy or funding REGULATORY CONTENT AND SUBMISSION Get the dose right for the right patient ● Evolving regulatory and compliance landscape • Global regulatory filings 53 REGULATORY AGENCIES CERTARA

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