2024 JP Morgan Healthcare Conference
BRUKER - AN EMERGING LEADER OF THE POST-GENOMIC ERA
Functional Structural Biology: Understanding Disease with GHz NMR
NMR in Pharmacology
NMR in (Un-)structural Biology
Intrinsically Disordered Proteins (IDPs)
GPCRs as Key Drug Targets
Liquid-Liquid
Phase Separation
which RNA
to choose?
IDPs implicated in protein aggregation in
Alzheimer's, Parkinson's, Diabetes-ll and
Creutzfeldt-Jakob diseases
NMR in RNA-Protein Complexes
Accelerates RNA Drug Discovery
▪ RNA structure & RNA-target interactions
▪ RNA pathways and RNA-binding
Antagonist
Spontaneous
transition
Inactive
Antagonist
selects inactive
receptor
conformation
Unfolded
Cycling
Agonist
www
Active
Agonist
selects active
receptor
conformation
Radio frequency
heating
Folded
BRUKER
▪ NMR key to G-Protein Coupled Receptors
(GPCR) conformational studies
NMR in 4D-Biology
Biological Processes in Space and Time
Innovation with Integrity
January 8, 2024View entire presentation