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Investor Presentaiton

4 Investor presentation Full year 2022 Novo NordiskⓇ Strategic Aspirations 2025 | Highlights full year 2022 Purpose and sustainability (ESG) Progress towards zero environmental impact Carbon emissions decreased by 29% vs 20191 Adding value to society Medical treatment provided to 36.3 million people living with diabetes Reaching more than 41,000 children in Changing Diabetes in Children programme Being recognised as a sustainable employer Share of women in VP+ positions increased to 39% from 36% in 2021 ピ Diabetes value market share increased by 1.8%-points to 31.9%3 Obesity care sales of DKK 16.9 billion (+84% at CER) Rare disease sales of DKK 20.5 billion (+1% at CER) Commercial execution therapeutic focus Innovation and Financials • • Light blue indicates developments in Q4 2022 Further raise innovation bar for Diabetes treatment Completion of phase 3a trials with QW insulin icodec Completion of phase 2 trial with CagriSema in T2D Develop superior treatment solutions for obesity Phase 3 initiated with CagriSema in people with obesity Strengthen and progress Rare disease pipeline • • • Concizumab phase 3 trial completed² Phase 3a trial initiated with Mim8 in Haemophilia A Establish presence in Other serious chronic diseases Two phase 1 trials initiated in NASH utilising siRNA Sales growth of 16% (CER) and Operating profit growth of 15% (CER) • . Sales in International Operations grew by 13% (CER) • Sales in the US grew by 19% (CER) with 73% of sales coming from products launched since 2015 Gross margin positively impacted by continued productivity gains in Product Supply Free cash flow of DKK 57.4 billion and DKK 49.4 billion returned to shareholders in 2022 1 Partial scope 3 limited to CO2 emissions from business flights and product distribution; 2in people with Haemophilia A and B with and without inhibitors; 3MAT (Moving annual total) value market share EMA: European Medicines Agency; VP: Vice president; QD: Once-daily; QW: Once-weekly; CER: Constant exchange rates; T2D: Type 2 diabetes; HA: Haemophilia A; HB: Haemophilia B; SCD: Sickle Cell Disease Note: The strategic aspirations are not a projection of Novo Nordisk's financial outlook or expected growth
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