Reimagining Medicine Q2 2023 Results slide image

Reimagining Medicine Q2 2023 Results

Company overview Financial review Conclusions Appendix References STRATEGY Recent deals to bolster pipeline and strengthen technology platforms including late stage assets in IgAN, early stage asset in CNS Announced acquisitions (selected) Clinical stage: IgAN1 CHINOOK™ THERAPEUTICS Atrasentan, Ph3 oral ERA, pivotal readout expected Q4 2023 Zigakibart, SC anti-APRIL, expected to enter Ph3 in H2 2023 Both have shown strong proteinuria reduction in Ph2 USD 3.2bn upfront (total consideration up to USD 3.5bn) Announced divestment Neuromuscular + technology Non-core front of eye assets¹ DTX PHARMA Lead early asset DTx1252 for Charcot-Marie-Tooth disease siRNA FALCON platform USD 0.5bn upfront Others Gene Therapy: Avrobio cystinosis program RLT: Ph1/2 FAP-2286 (Clovis Oncology) 1. Subject to customary closing conditions; closing expected H2 2023 APRIL - a proliferation inducing ligand. BAUSCH + LOMB incl. Xiidra, SAF312, OJL332 Supports focus in 5 TAs USD 1.75bn upfront (total consideration up to USD 2.5bn) Termination BeiGene option agreement for ociperlimab ERA endothelin A receptor antagonist. FALCON - fatty acid ligand conjugated oligonucleotides. IgAN - immunoglobulin A nephropathy. 17 Investor Relations | Q2 2023 Results ✓ NOVARTIS | Reimagining Medicine
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