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Investor Presentaiton

Case Study: Novel Treatment Age 60 Indications Sex Novel treatment for a Severe Progressive Silicosis related Occupational Lung Disease Baseline Summary • . At baseline, there are advanced changes of chronic, complicated silicosis as marked by nodular coalescence and fibrosis in the apical regions bilaterally, leading to progressive massive fibrosis. No significant structural changes are seen after treatment (on CT). Following treatment, there are functional improvements in all inspiratory metrics visible on XV LVAS. Notably, the right apical region with areas of relative underventilation (red shading) has markedly improved to average ventilation (green shading) following treatment. 3 Months Post-WLL Clinical Observations Quantifiable, regional improvements in inspiratory function have been observed following treatment for lung disease, which assists the clinician in monitoring treatment effectiveness. In comparison, serial chest CTs showed no significant change following this treatment TV Structural CT XV LVAS 0.5L TV Structural CT XV LVAS 0.6L 4DMedical™ VH 54.5% VDP 17.3% VH 47.3% VDP 13.5%
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