Investor Presentaiton

M1 Macrophage IL-6 in CKD-induced CVD 350 Million CKD Patients Worldwide at Risk of Having a CVD Cytokines, AGE Hypoxia Thrombin Ox LDL ification Vascular calcificat Monocyte/ Macrophages Endothelial Cells Smooth Muscle Cells IL-1ẞ, other cytokines IL-6 M2 Macrophage Osteoclast Cardiomyocytes Treg Th17 Circulation. 2020;141:787-789. Cardiomyocyte injury Collagen deposition/ Cardiac Fibrosis CRP, SAA, Fibrinogen ■ Approx. 700 million people worldwide live with ONENESS chronic kidney disease (CKD) which correlates with chronic inflammation. 50% CKD patients are with complication of cardiovascular diseases ■ Inflammation of CKD is correlated to the elevation of IL6. C-reactive protein (CRP) is the key indicator of inflammation. "IL-6 level and CKD status should be useful as decision support for selection of patients with chronic coronary syndrome who may derive benefit from anti- inflammatory treatment with general and specific IL-6 inhibition," | 24

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