Roche Pharmaceutical Development and Sales Overview slide image

Roche Pharmaceutical Development and Sales Overview

Al submissions for existing products Projects in phase II and III RG6264 Phesgo OBI HER2+ BC New Molecular Entity (NME) Additional Indication (Al) Oncology/Hematology Immunology Infectious Diseases Metabolism Neuroscience Ophthalmology Other Roche RG6396 Gavreto Tumor agnostic (US) Tecentriq + cabozantinib RG7446 2L NSCLC Kadcyla + Tecentriq RG3502 2L+ HER-2+ PD-L1+ mBC RG3502 Kadcyla + Tecentriq HER-2+ eBC high-risk Tecentriq + cabozantinib RG7446 RG7446 RCC adv Tecentriq + Avastin RG7446 RG7446 HCC adj RG6413+ Ronapreve** RG7446 RG6412 SARS-CoV-2 hospitalized (EU)✓ Tecentriq² NSCLC periadj RG1594 Ocrevus SC RMS & PPMS RG7446 Tecentriq + paclitaxel TNBC adj RG7159 Actemra RG1569 RG7446 COVID-19 pneumonia¹ ✓ Tecentriq SCCHN adj TNKase Tecentriq RG3625 RG7446 RG7159 stroke ctDNA+ high-risk MIBC Tecentriq High risk NMIBC Tecentriq+ lurbinectedin 1l maintenance SCLC Gazyva Gazyva systemic lupus erythematosus membranous nephropathy Tecentriq ± chemo Venclexta RG7446 RG7601 RG3648 1L MUC r/r MM t(11:14) Xolair food allergy RG7601 Venclexta + azacitidine 1L MDS Ocrevus higher dose RG1594 Tecentriq + capecitabine RG7446 Tecentriq SC 2L NSCLC RG7446 or carbo/gem RG6152 Xofluza direct transmission RG7159 Gazyva lupus nephritis RG6168 TNBC Xofluza RG7596 Polivy 1L DLBCL (US)✓ Alecensa RG7853 RG6152 ALK+ NSCLC adj influenza, pediatric (0-1 year) RG6168 Enspryng myasthenia gravis RMS & PPMS Enspryng MOG-AD Enspryng RG6168 autoimmune encephalitis 2022 2023 2024 2025 and beyond Status as of October 18, 2022 Indicates submission to health authorities has occurred Unless stated otherwise submissions are planned to occur in US and EU 1Approved in EU, filed in US 2filing timeline based on data from interim analysis PDS-Port Delivery System with ranibizumab OBI-On-Body Delivery System **Ronapreve (casirivimab+imdevimab also known as REGEN-COV in the US) developed in collaboration with Regeneron Pharmaceuticals 56
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