Q2 2021 Results - Reimagining Medicine slide image

Q2 2021 Results - Reimagining Medicine

Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix References 177Lu-PSMA-617 launch preparations are progressing, ready to meet immediate launch demand upon approval in US Prognosis remains poor for patients with mCRPC Most diagnosed cancer in men¹ 2nd >80% Of patients metastatic at the time of CRPC diagnosis² ~10 Months median OS on available treatment options³ Building foundation for strong launch upon approval in US ■ 177 Lu-PSMA-617 uniquely positioned to address unmet needs in mCRPC with strong data on OS (median OS 15.3 months) and rPFS Disease state education campaign on PSMA as an important phenotypic biomarker ■ Growth in PSMA awareness from 31% to 66% over last 12 months4 Focused on activating >200 top treatment centers at launch for PSMA ■ Expecting gradual ramp-up due to diagnostic, process set-up, licensure FDA BTD granted in June 2021 ■ Filing to FDA on track for H2 2021 See slide 55 for references. 29 Investor Relations | Q2 2021 Results 1 NOVARTIS | Reimagining Medicine
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