Investor Presentation - First Six Months of 2021

95 Investor presentation First six months of 2021 Insulin market size and volume market share in EMEA Insulin market share and market size (DKK billion) Total 48% Long- acting 39% Fast- 56% 11 acting 72% Premix 3 44% Human 3 18 Market growth A Market share Insulin volume: market share 80% 36 -4% +0.7% 60% -1% +1.5% 40% -2% +0.1% 20% -9% +1.0% 0% May 2018 -14% +0.2% NN market share EMEA 15% 13% 11% 9% 48% 7% 5% 3% 1% -1% 1% -3% May 2021 Novo Nordisk Competitors Source: IQVIA, May 2021, LHS graph - Value, RHS Graph - Volume, MAT, Europe, Middle East & Africa, Share of growth not depicted due to too high numbers; NN: Novo Nordisk -Market growth (right axis) NN growth (right axis)

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