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Investor Presentaiton

Investor Presentation First six months of 2018 Slide 53 Solid TresibaⓇ performance strengthens basal insulin market share in Japan Japanese basal value market shares TresibaⓇ NPH LevemirⓇ glargine U100 biosimilar glargine U100 - Novo Nordisk Japanese total insulin value market shares Eli Lilly - Sanofi glargine U300 NN Total Basal 80% 70% 60% 50% 40% 30% 20% 10% 0% May 2015 Source: IQVIA monthly MAT May, 2018 value figures changing diabetes 60% 51% 43% 40% 17% -16% 20% 14% 6% 2% 0% May 2018 May 2015 Source: IQVIA monthly MAT May, 2018 value figures 59% 22% 18% May 2018 novo nordisk

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