Pharma Update

Upcoming IR events on Neuroscience, Digitalization and Diagnostics Roche Neuroscience Update on Oct 30 Virtual event Neuroscience pipeline and strategy • Latest data on: • Ocrevus Ph III (OCARINA II) in MS • fenebrutinib Ph II (FENopta) in MS trontinemab Ph I dose escalation in AD GSM (Gamma secretase modulator) Ph I in AD Roche Digitalization Day on Nov 29 Virtual event Roche experts to present how digitalization (incl. RWD and Al/ML) transforms our Pharmaceuticals and Diagnostics businesses in an unprecedented way Use cases covering early R&D, clinical development, regulatory, manufacturing, supply chain and commercialization to be presented Discussion of novel product opportunities at the interface between Diagnostics and Pharmaceuticals • 999 Roche Diagnostics Day in H1 2024 Hybrid event (virtual/on-site) Management to update on Diagnostics mid- term outlook Deep-dives into the current product portfolio Updates on key development projects, including mass spectrometry (launch scheduled for 2024), continuous glucose monitoring (CGM) and next-generation sequencing (NGS) Angiogenesis 2023 Virtual Monday, 13 February 16:30 to 18:00 CET Roche ESG Day Virtual Tuesday, 23 May 15:30 to 17:00 CEST EHA 2023 Virtual Monday, 12 June 16:30 to 17:30 CEST Roche Pharma Day London Monday, 11 September 10:30 to 14:30 BST MS-multiple sclerosis; AD-Alzheimer's disease; RWD-real-world data; AI/ML-artificial intelligence and machine learning Neuroscience Update Virtual Roche Digitalization Day Virtual Monday, 30 October TBA Wednesday, 29 November TBA ASH 2023 Virtual December TBA Roche Diagnostics Day Virtual/hybrid H1 2024 TBA 36

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