Ocuphire Pharma Investor Update

9 CO Nyxol Product Candidate Profile Novel, Differentiated Alpha 1/2 Blocker Eye Drop for Refractive Indications Nyxol: 0.75% Phentolamine Ophthalmic Solution Preservative Free, EDTA Free, and Stable Favorable Safety Profile Efficacy Data Nyxol Improves Vision by Decreasing Pupil (~1-1.5mm) ↑ Near Vision ↑ Distance Vision ↑ Contrast Sensitivity (night) Nyxol Clinical Trials No Systemic Effects No Changes in Blood Pressure No Changes in Heart Rate Well-Tolerated Topical Effects Mild, Transient, Reversible Eye Redness IOP Unchanged or Decreased Minimal to No Headaches Durable Effects Last > 24 Hours Chronic daily dosing of Nyxol at bedtime reduces pupil size for up to 24 to 36 hours Ocuphire PHARMA

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