Ocuphire Pharma Investor Day Presentation Deck
P
77
What is the Optimal Pupil Size?
Literature Highlights New Drops to Treat Presbyopia Achieve Optimal Pupil Diameter of 2-3 mm
VSTOF (Constricted/natural)
100
10
0.1
Photopic Lighting (100 -1000 lux)
Natural Pupil Size ~ 4 mm
0%
NEAR
Vision
DISTANCE
Vision
Optimum
2.0-3.0 mm
20%
60%
80%
% Constricted Pupil Size of Natural Pupil
40%
TT
Natural
Pupil
100%
Effect of Target Luminance on Optimum Pupil
Diameter for Presbyopic Eyes
Renfeng Xu*, Larry Thibos, and Arthur Bradley*
"A fixed 2- to 3-mm small pupil or a 30% pupil miosis can
both produce near visual acuity gains without significant
losses to distance acuity or image quality, and therefore
can be considered as optimal for a presbyope experiencing
a wide range of light levels."
- Optometry and Vision Science, November 2016
WHAT IS THE OPTIMAL PUPIL SIZE?
OF
This question is becoming increasingly relevant as small-aperture IOLs and
pupil-modulating drops are developed to treat presbyopia.
BY JAY S. PEPOSE, MD, PHD, AND RENFENG "RENA XU, MD, PHD
CATARACT SURGERY
"The impact of pupillary modulation on the functional
depth of field differs among patients with refractive error
versus those who are truly emmetropic.
""
- Cataract & Refractive Surgery Today (CSRT), January 2022
Source: Xu et al, OVS 2016; Pepose & Xu CSRT article 2022, Effect of Target Luminance on Optimum Pupil Diameter for Presbyopic Eyes
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