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Investor Presentation

131 Investor presentation First six months of 2022 North America Operations at a glance. NAO Diabetes trend in population Diabetes market by value and Novo Nordisk market share Novo Nordisk reported sales Million DKK billion First half of 2022 Sales (mDKK) Growth² 70 10% 600 80% Total GLP-13 24,638 41% 60 11% Long-acting insulin4 2,880 -22% 50 60% Premix insulin5 271 -11% 400 36.8%¹ GLP-1 Fast-acting insulin 3,040 -16% 40 Human insulin 788 -3% 40% 30 63 Total insulin 6,979 -18% 57 51 1.4%1 Insulin 20 20 200 Other Diabetes care? 383 -29% 20% 10 13.2%1 OAD Diabetes care Obesity care 32,000 21% 4,565 102% 0 2021 0 0% Diabetes & Obesity May 2030 2045 2017 Population with diabetes Diabetes growth rate GLP-1 MS Insulin MS May 2022 OAD MS 36,565 27% care Rare disease⁹ 4,128 -1% Total 40,693 24% International Diabetes Federation: Diabetes Atlas 1th Edition 2000 and Diabetes Atlas 10th Edition 2021 1 CAGR calculated for 5-year period Competitor insulin value market shares, as of May 2022: Novo Nordisk 42%, Eli Lilly 30% and Sanofi 27%; Competitor GLP-1 value market shares, as of May 2022: Novo Nordisk 53%, Eli Lilly 44% and AstraZeneca 3% OAD: Oral anti-diabetic; MS: Market Share; Source: IQVIA MAT, May 2022 value figures 2 At constant exchange rates; 3 Comprises Victoza®, Ozempic®, and RybelsusⓇ; 4 Comprises Tresiba®, XultophyⓇ and LevemirⓇ: 5 Comprises NovoMix®; 6 Comprises FiaspⓇ and NovoRapidⓇ; 7 Comprises Novo NormⓇ and needles; 8 Comprises SaxendaⓇ and Wegovy 9 Comprises primarily NovoSevenⓇ, NovoEight® Esperoct®, NovoThirteen®, Refixia®, Norditropin®, VagifemⓇ and Activelle® Source: Quarterly company announcement
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