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Investor Presentation

14 Investor presentation First six months of 2022 R&D milestones for 2022 Project Diabetes care FDC Sema OW GIP Q2 2022 Phase 1 results Obesity care CagriSema T2DM RybelsusⓇ Icodec Higher doses inj. sema Oral FDC sema/SGLT2i SELECT CVOT CagriSema Oral amycretin Rare disease Other serious chronic diseases CN submission Novo NordiskⓇ Clinical milestones¹ Regulatory milestones¹ Q3 2022 Q4 2022 Phase 2 results Phase 3a results Phase 2 initiation Phase 1 initiation Interim analysis Phase 1 initiation LA-GDF15 Phase 1 results Sogroya® (somapacitan) Mim8 US/EU/JP submission (GHD) Phase 3 initiation Phase 3 treatment² Concizumab US/JP submission (HwI) Phase 3a results (HA/HB) NDec (Sickle cell disease) NNC6019 (ATTR-CM) Phase 2 initiation Phase 2 initiation 1 Expected to be published in the given quarter or in the subsequent quarterly company announcement. 2 First patient first visit in Q4 2021, which is solely for baselining purposes GHD: Growth Hormone Deficiency; sema: semaglutide; HwI: Haemophilia with inhibitors; ATTR-CM: Transthyretin Amyloid Cardiomyopathy; CVOT: Cardiovascular Outcomes Trial, FDC: Fixed dose combination; NDec was previously known as Eclipse and NNC6019 was previously known as PRX004
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