Moderna 2022 Priorities and Capital Allocation

Neutralizing antibody responses against ancestral SARS-CoV-2, Beta, Delta and Omicron after booster dose of .211 were higher than after booster dose of 1273 Spike-pseudotyped lentivirus neutralization assay ID 50 Neutralizing antibody GMT (95% CI) Slide 19 10,000- Ancestral SARS-CoV-2 with D614G mRNA-1273 50 μg mRNA-1273.211 1,000- 100- 10 150 H 1952 673 H Day 181 Pre-booster Day 29 Ha 103 Beta Delta mRNA-1273 50 μg mRNA-1273.211 50 μα mRNA-1273 50 μg mRNA-1273.211 50 μg 10,000- 50 μg 10,000- 10,000 2172 1006 Pre-booster Day 29 Day 181 1,000 100 38 10 H 921 1032 H 139 H 26 828 1,000- 397 326 H Pre-booster Day 29 Day 181 Pre-booster Day 29 Day 181 Chalkias, Spyros et al. https://www.researchsquare.com/article/rs-1555201/v1 100 47 10 53 H 1507 Omicron mRNA-1273 50 μα 1,000- 629 499 | Day 181 Pre-booster Day 29 Day 181 Pre-booster Day 29 100- 38 10 H 146 mRNA-1273.211 39 50 μg 1408 317 Day 181 Pre-booster Day 29 Day 181 Pre-booster Day 29 moderna

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