IPTACOPAN ASH UPDATE

Iptacopan has the potential to become the new SoC in a well established and growing global PNH market PNH complement inhibitors market size is estimated at ~USD 2bn¹ PNH market is expected to grow at 7.6% CAGR over the next 10 years in the 7 major markets² driven by new entrants and increased penetration of complement inhibitors³ Current total C5 inhibitor sales in PNH roughly evenly split between US and ex-US1 Significant opportunities ex-US, including China, where until recently there were no complement inhibitors available 1. Evaluate Pharma Dec 2022. 2. 7 Major Markets: US, Germany, France, UK, Italy, Spain and Japan. 3. Delveinsights PNH market report 2022. 33 NOVARTIS | Reimagining Medicine

View entire presentation