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Investor Presentaiton

Manufacturing Solutions Segment Safe production and release of manufactured products - Microbial Solutions Rapid, efficient testing platform for microbial detection and identification of sterile and non- sterile applications • • Leading global provider of quality-control (QC) testing products and services FDA-mandated lot release testing for sterile biopharmaceutical products Market-leading platforms EndosafeⓇ endotoxin detection AccugenixⓇ microbial identification and strain typing CelsisⓇ rapid microbial detection - Biologics Testing Process development and quality- control testing to support the manufacture of biologics Premier global partner in navigating the complex pathway to biologic effectiveness Supports developers and manufacturers with their testing, characterization, and cell bank manufacturing needs Testing and assay development throughout drug development, clinical, and commercial manufacturing - ន C&GT CDMO Scientific partner for C&GT development, testing, and manufacturing Solutions across all major CDMO platforms for C&GT Primary expertise in gene- modified cell therapy with growing capabilities in gene therapy, including plasma DNA and viral vectors Excellent strategic fit across CRL portfolio Integrated value chain from foundational cellular materials through analytical testing and the production of advanced therapies -70% of Microbial Solutions revenue from reagents/consumables, creating a recurring revenue stream -65% of CRL's C&GT CDMO revenue from gene-modified cell therapy production Hannah charles rive Charles River Laboratories (CRL) 12
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