Corporate Presentation

Obesity Petrelintide Native amylin is a non-incretin peptide that increases satiety in contrast to GLP-1, which reduces appetite Mechanism of action A 37-amino acid peptide hormone, produced mainly in the pancreatic beta cells and co-secreted with insulin in response to ingested nutrients Proposed physiological effects of amylin receptor activation¹ Pancreas (indirect)a ↓ Insulin secretion ↓ Glucagon secretion Liver and adipose tissue ↑ Insulin sensitivity Amylin ZEAL& ZEALAND PHARMA CNS (↑ Leptin sensitivity² ↑ Satiety Energy expenditure ↓Body weight Via the vagal nerve ↓ Fat accumulation aMediated by the effect of amylin on the CNS. Sources: 1. Figure adapted from Mathiesen et al. Eur J Endocrinol 2022;186(6):R93-R111; 2. Roth et al. Proc Natl Acad Sci USA 2008;105(20):7257-7262. CNS=central nervous system; Gl=gastrointestinal; GLP-1=glucagon-like peptide-1. GI tract ↓ Gastric emptying 13

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