Investor Presentaiton

Portfolio Considerations ■ Safeguard Market Cap < Fair Market Value< Projected Future Exit Values • Carrying value does not equal Fair Market Value due to equity method accounting • • • Fair Market Values calculated from widely accepted methodologies - recent financings, company performance and public markets data Projected Future Exit Values dependent on sector, company execution, capital availability, and M&A markets Recent public market peer group for tech-enabled healthcare and ad tech trade companies both trade at ~6x 2021 consensus revenues ■ Strict portfolio management philosophy to optimize value-maximization and time to exit ■ Pursue multiple avenues to achieve exits . Board influence to accelerate exit processes Company sale or IPOS ("natural exit") are the preferred approaches to maximize value • Also explore secondary and structured transactions for specific situations ■ Virtual discussions with 5 portfolio company CEOs hosted during the year and available for replay at: https://ir.safeguard.com/investors/events-and-presentations/past- events/default.aspx • Replays currently available for: meQuilibrium, Flashtalking, Aktana, Prognos and InfoBionic G www.safeguard.com SFE © 2021 Safeguard Scientifics, Inc. All rights reserved. LISTED NYSE 6

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