Roche Pharmaceutical Development and Sales Overview

TNKase / Activase Global sales CHFbn CER growth -8% Regional sales CER growth US -9% 1.2 1.0 0.8 0.6 0.4 0.2 0.0 YTD Sep 19 YTD Sep 20 YTD Sep 21 YTD Sep 22 YTD Sep 2022 sales of CHF 881m • US: Sales impacted by COVID-19 and purchasing patterns CER-Constant Exchange Rates International +5% Roche 162

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