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Investor Presentaiton

| Growth & Launch Products Driving Topline & Profit Growth Strong FY2022 H1 Performance Takeda On Track to Full-year FY2022 Guidance st 4 Core Revenue +5.5% at CER1,2 Revenue Core EPS Core EPS +15.8% JPY 3,930B 525 yen at CER1,2 (USD $29.7B)³ (USD $3.97)³ Growth & Launch Products +19% at CER1,2 represent 38% of total revenue Core Operating Profit Margin 31.7% FY2022 MANAGEMENT GUIDANCE CORE REVENUE CORE OPERATING PROFIT CORE EPS GROWTH AT CER² Low-single-digit growth High-single-digit growth High-single-digit growth 1. Please refer to appendix slide 15 for definition of core financial measures and slides 16-19 for reconciliation. 2. Constant Exchange Rate. Please refer to appendix slide 15 for definition. 3. Forecast in USD given for reference using full-year FX rate assumption of 132.4 JPY/USD. This reflects H1 at actual FX and applies the Apr-Oct 2022 average rate to H2 projections.
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